358 research outputs found
Complex dynamics of an optically injected semiconductor laser : bifurcation theory and experiment
In this paper unprecedented agreement is reported between a theoretical two-dimensional bifurcation diagram and the corresponding experimental stability map of an optically injected semiconductor laser over a large range of relevant injection parameter values. The bifurcation diagram encompasses both local and global bifurcations mapping out regions of regular, chaotic and multistable behavior in considerable detail
Shape analysis on homogeneous spaces: a generalised SRVT framework
Shape analysis is ubiquitous in problems of pattern and object recognition
and has developed considerably in the last decade. The use of shapes is natural
in applications where one wants to compare curves independently of their
parametrisation. One computationally efficient approach to shape analysis is
based on the Square Root Velocity Transform (SRVT). In this paper we propose a
generalised SRVT framework for shapes on homogeneous manifolds. The method
opens up for a variety of possibilities based on different choices of Lie group
action and giving rise to different Riemannian metrics.Comment: 28 pages; 4 figures, 30 subfigures; notes for proceedings of the Abel
Symposium 2016: "Computation and Combinatorics in Dynamics, Stochastics and
Control". v3: amended the text to improve readability and clarify some
points; updated and added some references; added pseudocode for the dynamic
programming algorithm used. The main results remain unchange
Fiber-Flux Diffusion Density for White Matter Tracts Analysis: Application to Mild Anomalies Localization in Contact Sports Players
We present the concept of fiber-flux density for locally quantifying white
matter (WM) fiber bundles. By combining scalar diffusivity measures (e.g.,
fractional anisotropy) with fiber-flux measurements, we define new local
descriptors called Fiber-Flux Diffusion Density (FFDD) vectors. Applying each
descriptor throughout fiber bundles allows along-tract coupling of a specific
diffusion measure with geometrical properties, such as fiber orientation and
coherence. A key step in the proposed framework is the construction of an FFDD
dissimilarity measure for sub-voxel alignment of fiber bundles, based on the
fast marching method (FMM). The obtained aligned WM tract-profiles enable
meaningful inter-subject comparisons and group-wise statistical analysis. We
demonstrate our method using two different datasets of contact sports players.
Along-tract pairwise comparison as well as group-wise analysis, with respect to
non-player healthy controls, reveal significant and spatially-consistent FFDD
anomalies. Comparing our method with along-tract FA analysis shows improved
sensitivity to subtle structural anomalies in football players over standard FA
measurements
Femtosecond formation dynamics of the spin Seebeck effect revealed by terahertz spectroscopy.
Understanding the transfer of spin angular momentum is essential in modern magnetism research. A model case is the generation of magnons in magnetic insulators by heating an adjacent metal film. Here, we reveal the initial steps of this spin Seebeck effect with <27 fs time resolution using terahertz spectroscopy on bilayers of ferrimagnetic yttrium iron garnet and platinum. Upon exciting the metal with an infrared laser pulse, a spin Seebeck current js arises on the same ~100 fs time scale on which the metal electrons thermalize. This observation highlights that efficient spin transfer critically relies on carrier multiplication and is driven by conduction electrons scattering off the metal-insulator interface. Analytical modeling shows that the electrons' dynamics are almost instantaneously imprinted onto js because their spins have a correlation time of only ~4 fs and deflect the ferrimagnetic moments without inertia. Applications in material characterization, interface probing, spin-noise spectroscopy and terahertz spin pumping emerge
Efficient Construction of an Inverted Minimal H1 Promoter Driven siRNA Expression Cassette: Facilitation of Promoter and siRNA Sequence Exchange
RNA interference (RNAi), mediated by small interfering RNA (siRNA), is an effective method used to silence gene expression at the post-transcriptional level. Upon introduction into target cells, siRNAs incorporate into the RNA-induced silencing complex (RISC). The antisense strand of the siRNA duplex then "guides" the RISC to the homologous mRNA, leading to target degradation and gene silencing. In recent years, various vector-based siRNA expression systems have been developed which utilize opposing polymerase III promoters to independently drive expression of the sense and antisense strands of the siRNA duplex from the same template.We show here the use of a ligase chain reaction (LCR) to develop a new vector system called pInv-H1 in which a DNA sequence encoding a specific siRNA is placed between two inverted minimal human H1 promoters (approximately 100 bp each). Expression of functional siRNAs from this construct has led to efficient silencing of both reporter and endogenous genes. Furthermore, the inverted H1 promoter-siRNA expression cassette was used to generate a retrovirus vector capable of transducing and silencing expression of the targeted protein by>80% in target cells.The unique design of this construct allows for the efficient exchange of siRNA sequences by the directional cloning of short oligonucleotides via asymmetric restriction sites. This provides a convenient way to test the functionality of different siRNA sequences. Delivery of the siRNA cassette by retroviral transduction suggests that a single copy of the siRNA expression cassette efficiently knocks down gene expression at the protein level. We note that this vector system can potentially be used to generate a random siRNA library. The flexibility of the ligase chain reaction suggests that additional control elements can easily be introduced into this siRNA expression cassette
Recognizing recurrent neural networks (rRNN): Bayesian inference for recurrent neural networks
Recurrent neural networks (RNNs) are widely used in computational
neuroscience and machine learning applications. In an RNN, each neuron computes
its output as a nonlinear function of its integrated input. While the
importance of RNNs, especially as models of brain processing, is undisputed, it
is also widely acknowledged that the computations in standard RNN models may be
an over-simplification of what real neuronal networks compute. Here, we suggest
that the RNN approach may be made both neurobiologically more plausible and
computationally more powerful by its fusion with Bayesian inference techniques
for nonlinear dynamical systems. In this scheme, we use an RNN as a generative
model of dynamic input caused by the environment, e.g. of speech or kinematics.
Given this generative RNN model, we derive Bayesian update equations that can
decode its output. Critically, these updates define a 'recognizing RNN' (rRNN),
in which neurons compute and exchange prediction and prediction error messages.
The rRNN has several desirable features that a conventional RNN does not have,
for example, fast decoding of dynamic stimuli and robustness to initial
conditions and noise. Furthermore, it implements a predictive coding scheme for
dynamic inputs. We suggest that the Bayesian inversion of recurrent neural
networks may be useful both as a model of brain function and as a machine
learning tool. We illustrate the use of the rRNN by an application to the
online decoding (i.e. recognition) of human kinematics
Shape description and matching using integral invariants on eccentricity transformed images
Matching occluded and noisy shapes is a problem frequently encountered in medical image analysis and more generally in computer vision. To keep track of changes inside the breast, for example, it is important for a computer aided detection system to establish correspondences between regions of interest. Shape transformations, computed both with integral invariants (II) and with geodesic distance, yield signatures that are invariant to isometric deformations, such as bending and articulations. Integral invariants describe the boundaries of planar shapes. However, they provide no information about where a particular feature lies on the boundary with regard to the overall shape structure. Conversely, eccentricity transforms (Ecc) can match shapes by signatures of geodesic distance histograms based on information from inside the shape; but they ignore the boundary information. We describe a method that combines the boundary signature of a shape obtained from II and structural information from the Ecc to yield results that improve on them separately
Force of tuberculosis infection among adolescents in a high HIV and TB prevalence community: a cross-sectional observation study
BACKGROUND: Understanding of the transmission dynamics of tuberculosis (TB) in high TB and HIV prevalent settings is required in order to develop effective intervention strategies for TB control. However, there are little data assessing incidence of TB infection in adolescents in these settings. METHODS: We performed a tuberculin skin test (TST) and HIV survey among secondary school learners in a high HIV and TB prevalence community. TST responses to purified protein derivative RT23 were read after 3 days. HIV-infection was assessed using Orasure(R) collection device and ELISA testing. The results of the HIV-uninfected participants were combined with those from previous surveys among primary school learners in the same community, and force of TB infection was calculated by age. RESULTS: The age of 820 secondary school participants ranged from 13 to 22 years. 159 participants had participated in the primary school surveys. At a 10 mm cut-off, prevalence of TB infection among HIV-uninfected and first time participants, was 54% (n = 334/620). HIV prevalence was 5% (n = 40/816). HIV infection was not significantly associated with TST positivity (p = 0.07). In the combined survey dataset, TB prevalence was 45% (n = 645/1451), and was associated with increasing age and male gender. Force of infection increased with age, from 3% to 7.3% in adolescents [greater than or equal to]20 years of age. CONCLUSIONS: We show a high force of infection among adolescents, positively associated with increasing age. We postulate this is due to increased social contact with infectious TB cases. Control of the TB epidemic in this setting will require reducing the force of infection
On the beneficial effect of noise in vertex localization
A theoretical and experimental analysis related to the effect of noise in the task of vertex identication in unknown shapes is presented. Shapes are seen as real functions of their closed boundary. An alternative global perspective of curvature is examined providing insight into the process of noise- enabled vertex localization. The analysis reveals that noise facilitates in the localization of certain vertices. The concept of noising is thus considered and a relevant global method for localizing Global Vertices is investigated in relation to local methods under the presence of increasing noise. Theoretical analysis reveals that induced noise can indeed help localizing certain vertices if combined with global descriptors. Experiments with noise and a comparison to localized methods validate the theoretical results
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